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Alma universitas studiorum parmensis A.D. 962 - Università di Parma Alma universitas studiorum parmensis A.D. 962 - Università di Parma
Department of
Mathematical, Physical and Computer Sciences
Università degli Studi di Parma

Biophysics

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Welcome to the web pages of the Biophysics section at the Department of Mathematical, Physical and Computer Sciences. 
Research in molecular Biophysics has a longstanding tradition in Parma, dating back to the 60's.The Italian Biophysical Society SIBPA (Società Italiana di Biofisica Pura ed Applicata) was founded in Parma in 1973. Nowadays, researchers active in this Department apply spectroscopic and computational methods to study structural and dynamical properties of biological macromolecules and their interactions with the environment. 

News

2026 Nobel Prize in Medicine celebrates the pioneers of optogenetics

The 2026 Nobel Prize in Physiology or Medicine has been awarded to Karl Deisseroth, Peter Hegemann and Georg Nagel for their pioneering discoveries in optogenetics, a field that has revolutionized our ability to investigate and control biological processes using light.

Building on fundamental studies of microbial photoreceptors, particularly algal channelrhodopsins, their research established the foundations of a technology that enables the precise and timely optical control of cellular activity. Initially developed for neuroscience, optogenetics has since expanded into many areas of biology and biomedicine, providing powerful tools to manipulate ion transport, intracellular signaling and cellular functions.

The Italian biophysics community has also contributed to research in this rapidly evolving field. In particular, Aba Losi, of the Biophysics Group at the University of Parma, has collaborated with Nobel laureates Peter Hegemann and Georg Nagel on several studies investigating the molecular mechanisms of light-sensitive proteins and their potential as optogenetic tools.These collaborations, resulting in four joint publications between 2004 and 2013, addressed the photophysical properties of LOV (Light, Oxygen, Voltage) domains and the characterization of light-activated adenylyl cyclases, including bPAC, a small bacterial enzyme capable of controlling intracellular cAMP levels upon illumination. These studies illustrate how fundamental investigations into the molecular mechanisms of biological photoreception can contribute to the development of new approaches for the optical control of cellular processes.

The 2026 Nobel Prize is a remarkable recognition of the transformative potential of photobiophysics and of the importance of fundamental research at the interface between physics and biology.

Research topics

The development of genetically encoded photoswitchable fluorescent proteins is of greatest interest to expand the toolkit of fluorescent reporters suitable for super-resolution microscopy applications based on random activation of single molecules. We are exploiting YtvA, a photochromicblue light photoreceptor from Bacillus subtilis, as a fluorescent probe for superresolution microscopy. Current efforst include novel GAF domains.

protein-based nanocarrier for photodynamic therapy

We exploit proteins as nanosized carriers for photosensitizers. The nanostructured materials are inherently theranostic devices, with built in terapeutic (photosensitized production of singlet oxygen) and diagnostic (through their fluorescence emission) capabilities.

ligand accessibility in hemeproteins

The presence of cavities and tunnels in the interior of proteins, in conjunction with the structural plasticity arising from the coupling to the thermal fluctuations of the protein scaffold, has profound consequences on the pathways followed by ligands moving through the protein matrix. Through an integrated approach using quantitative analysis of experimental rebinding kinetics from laser flash photolysis, trapping of unstable conformational states by embedding proteins within the nanopores of silica gels, and molecular simulations we try to gain insight into the migration mechanism of ligands.

Structure and dynamics of different protein systems are investigated by means of molecular dynamics simulations, molecular docking and molecular modeling techniques. The study of a genetic mutation affecting protein HFE and causing Hemochromatosis disease, and  the study of the behavior of SMN protein involved in Spinal Muscular Atrophy pathology are the more recent topics.  Collagen assembly and dehydration, interaction of Myelin Basic Protein with membrane (with implication in Multiple Sclerosis disease), genetically encoded photosensitisers for singlet oxygen (with potential application in photodynamic therapy of cancer), are just a few other examples of the systems under study.

People

Our research group

  • Martina Simeone (40° ciclo)
  • Carlotta Viappiani (40° ciclo)
  • Lucia Bellanova (39° ciclo)
  • Dario Santantonio (39° ciclo)
  • Martina Buccardi (38° ciclo)
  • Margherita Lofrumento
  • Simone Civita
  • Manuela Maria Alampi
  • Matteo Mariangeli
  • Eleonora Uriati
  • Francesco Garzella
  • Ludovica Leo
  • Eleonora Consiglieri
  • Chiara Montali
  • Ilaria Menozzi
  • Chiaramaria Stani
  • Carmen Mandalari
  • Alessandro Allegri
  • Elena Grandi
  • Valentina Buttani
  • Anna Pezzarossa
  • Elsa Livoti
  • Elena Decaneto
  • Francesca Pennacchietti
  • Matteo Gabba

Lab facilities

laser flash photolysis equipment

Our laboratories are equipped with steady state and time resolved spetroscopic methods which include UV-VIS spectrophotometers, FTIR,  fluorimeter, laser flash photolysis, Fuorescence Correlation Spectroscopy (FCS), time resolved photoacoustics and a fluorescence microscope for single-molecule localization microscopy. We have also access to the UniPR HPC supercomputing cluster. Details of available lab facilities.

Research Projects

  • A molecular platform for intracellular nitric oxide sensing (PLINIOS) - PRIN: PROGETTI DI RICERCA DI RILEVANTE INTERESSE NAZIONALE – Bando 2022 PNRR. Prof. Cristiano Viappiani
  • Novel protein-based Genetically-Encoded Fluorescent Indicators (GEFI) for Functional Super-Resolution Imaging of Biomolecular Activities in Living Cells (GEFInder) - PRIN: PROGETTI DI RICERCA DI RILEVANTE INTERESSE NAZIONALE – Bando 2022 PNRR. Prof. Cristiano Viappiani

Publications

  • A semi‑automatic pipeline integrating histological and μCT data in a mouse model of lung fibrosis / Vincenzi E.; Buccardi M.; Ferrini E.; Fantazzini A.; Polverini E.; Villetti G.; Sverzellati N.; Aliverti A.; Basso C.; Pennati F.; Stellari F.F. - JOURNAL OF TRANSLATIONAL MEDICINE - 22:1040(2024). [10.1186/s12967-024-05819-y]
  • Insights on the Mechanical Properties of SARS-CoV-2 Particles and the Effects of the Photosensitizer Hypericin / Mariangeli, M.; Moreno, A.; Delcanale, P.; Abbruzzetti, S.; Diaspro, A.; Viappiani, C.; Bianchini, P. - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES - 25:16(2024). [10.3390/ijms25168724]
  • Fluorescence Correlation Spectroscopy as a Versatile Method to Define Aptamer–Protein Interactions with Single-Molecule Sensitivity / Porciani, D.; Alampi, M. M.; Abbruzzetti, S.; Viappiani, C.; Delcanale, P. - ANALYTICAL CHEMISTRY - 96:1(2024), pp. 137-144. [10.1021/acs.analchem.3c03341]
  • Kinetic and dynamical properties of truncated hemoglobins of the Antarctic bacterium Pseudoalteromonas haloplanktis TAC125 / de Armiño, D. J. A.; Di Lella, S.; Montepietra, D.; Delcanale, P.; Bruno, S.; Giordano, D.; Verde, C.; Estrin, D. A.; Viappiani, C.; Abbruzzetti, S. - PROTEIN SCIENCE - 33:7(2024). [10.1002/pro.5064]
  • Concanavalin A Delivers a Photoactive Protein to the Bacterial Wall / Mussini, A.; Delcanale, P.; Berni, M.; Pongolini, S.; Jordà-Redondo, M.; Agut, M.; Steinbach, P. J.; Nonell, S.; Abbruzzetti, S.; Viappiani, C. - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES - 25:11(2024), p. 5751. [10.3390/ijms25115751]
  • One substrate many enzymes virtual screening uncovers missing genes of carnitine biosynthesis in human and mouse / Malatesta, M.; Fornasier, E.; Di Salvo, M. L.; Tramonti, A.; Zangelmi, E.; Peracchi, A.; Secchi, A.; Polverini, E.; Giachin, G.; Battistutta, R.; Contestabile, R.; Percudani, R. - NATURE COMMUNICATIONS - 15:1(2024), pp. 3199.1-3199.16. [10.1038/s41467-024-47466-3]
  • Effect of E134K pathogenic mutation of SMN protein on SMN-SmD1 interaction, with implication in spinal muscular atrophy: a molecular dynamics study / Polverini, E.; Squeri, P.; Gherardi, V. - INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES - 275:(2024), pp. 133663-133678. [10.1016/j.ijbiomac.2024.133663]
  • A Photoactive Supramolecular Complex Targeting PD-L1 Reveals a Weak Correlation between Photoactivation Efficiency and Receptor Expression Levels in Non-Small-Cell Lung Cancer Tumor Models / Delcanale, P.; Alampi, M. M.; Mussini, A.; Fumarola, C.; Galetti, M.; Petronini, P. G.; Viappiani, C.; Bruno, S.; Abbruzzetti, S. - PHARMACEUTICS. - 15:12(2023), p. 2776 [10.3390/pharmaceutics15122776]
  • New Insights into the Enhancement of Adventitious Root Formation Using N,N′-Bis(2,3-methylenedioxyphenyl)urea / Ricci, A.; Polverini, E.; Bruno, S.; Dramis, L.; Ceresini, D.; Scarano, A.; Diaz-Sala, C. - PLANTS. - 12:20(2023), pp. 3610-3630. [10.3390/plants12203610]
  • Time-resolved photoacoustics of channelrhodopsins: early energetics and light-driven volume changes / Walter, M.; Schubert, L.; Heberle, J.; Schlesinger, R.; Losi, A. - PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES - 22:(2023), pp. 477-486. [10.1007/s43630-022-00327-8]
  • Oxygen diffusion pathways in mutated forms of a LOV photoreceptor from Methylobacterium radiotolerans: a molecular dynamics study / Zerlotti, R., Losi A., Polverini E. - BIOMOLECULAR CONCEPTS. - 13:1(2022), pp. 164–174 [10.1515/bmc-2022-0013]
  • A photosensitizing fusion protein with targeting capabilities / Bruno, S.; Margiotta, M.; Cozzolino, M.; Bianchini, P.; Diaspro, A.; Cavanna, L.; Tognolini, M.; Abbruzzetti, S.; Viappiani, C. - BIOMOLECULAR CONCEPTS. - 13:1(2022), pp. 175-182. [10.1515/bmc-2022-0014]
  • A red-green photochromic bacterial protein as a new contrast agent for improved photoacoustic imaging / Garzella, Francesco; Bianchini, Paolo; Diaspro, Alberto; Losi, Aba; Gärtner, Wolfgang; Abbruzzetti, Stefania; Viappiani, Cristiano. - 26(2022), p. 100358. [10.1016/j.pacs.2022.100358]
  • Targeted photoimmunotherapy for cancer / Mussini, A.; Uriati, E.; Bianchini, P.; Diaspro, A.; Cavanna, L.; Abbruzzetti, S.; Viappiani, C. - BIOMOLECULAR CONCEPTS. - 5021. - 13:1(2022), pp. 126-147. [10.1515/bmc-2022-0010]
  • The Interaction of Hypericin with SARS-CoV-2 Reveals a Multimodal Antiviral Activity / Delcanale, P.; Uriati, E.; Mariangeli, M.; Mussini, A.; Moreno, A.; Lelli, D.; Cavanna, L.; Bianchini, P.; Diaspro, A.; Abbruzzetti, S.; Viappiani, C. - ACS APPLIED MATERIALS & INTERFACES. - 14:12(2022), pp. 14025-14032. [10.1021/acsami.1c22439]
  • From hemoglobin allostery to hemoglobin-based oxygen carriers / Faggiano, S.; Ronda, L.; Bruno, S.; Abbruzzetti, S.; Viappiani, C.; Bettati, S.; Mozzarelli, A. - MOLECULAR ASPECTS OF MEDICINE. - 84(2022), p. 101050.101050. [10.1016/j.mam.2021.101050]
  • Photodynamic treatment of pathogens / Delcanale, P.; Abbruzzetti, S.; Viappiani, C. - LA RIVISTA DEL NUOVO CIMENTO DELLA SOCIETÀ ITALIANA DI FISICA. - (2022). [10.1007/s40766-022-00031-4]
  • A Double Payload Complex between Hypericin and All-trans Retinoic Acid in the β-Lactoglobulin Protein / Rodriguez-Amigo, B.; Hally, C.; Roig-Yanovsky, N.; Delcanale, P.; Abbruzzetti, S.; Agut, M.; Viappiani, C.; Nonell, S. - ANTIBIOTICS.  - 11:2(2022). [10.3390/antibiotics11020282]
  • Probing the Role of Murine Neuroglobin CDloop-D-Helix Unit in CO Ligand Binding and Structural Dynamics / Exertier, Cécile; Sebastiani, Federico; Freda, Ida; Gugole, Elena; Cerutti, Gabriele; Parisi, Giacomo; Montemiglio, Linda Celeste; Becucci, Maurizio; Viappiani, Cristiano; Bruno, Stefano; Savino, Carmelinda; Zamparelli, Carlotta; Anselmi, Massimiliano; Abbruzzetti, Stefania; Smulevich, Giulietta; Vallone, Beatrice. - ACS CHEMICAL BIOLOGY. -8929. - 17:8(2022), pp. 2099-2108. [10.1021/acschembio.2c00172]
  • Versatile Supramolecular Complex for Targeted Antimicrobial Photodynamic Inactivation / Mussini, A.; Uriati, E.; Hally, C.; Nonell, S.; Bianchini, P.; Diaspro, A.; Pongolini, S.; Delcanale, P.; Abbruzzetti, S.; Viappiani, C. - BIOCONJUGATE CHEMISTRY. - 33:4(2022), pp. 666-676. [10.1021/acs.bioconjchem.2c00067]
  • Time-resolved photoacoustics of channelrhodopsins: early energetics and light-driven volume changes / Walter, Maria; Schubert, Luiz; Heberle, Joachim; Schlesinger, Ramona; Losi, Aba. - PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES. - (2022). [10.1007/s43630-022-00327-8]
  • Using Steady-State Kinetics to Quantitate Substrate Selectivity and Specificity: A Case Study with Two Human Transaminases / Peracchi, A.; Polverini, E. - MOLECULES. - 27:4(2022), p. 1398.1398. [10.3390/molecules27041398]
  • Targeted photoimmunotherapy for cancer / Mussini, A.; Uriati, E.; Bianchini, P.; Diaspro, A.; Cavanna, L.; Abbruzzetti, S.; Viappiani, C. - BIOMOLECULAR CONCEPTS. - 13:1(2022), pp. 126-147. [10.1515/bmc-2022-0010
  1. A novel targeting approach for melanoma cancer treatment based on photodynamic therapy / Uriati, E.; Viappiani, C.; Bianchini, P.; Diaspro, A.; Abbruzzetti, S. – Il Nuovo Cimento, 44:4-5(2021). [10.1393/ncc/i2021-21142-2]
  2. Photosensitizing proteins for a targeted antibacterial photodynamic inactivation / Mussini, A.; Hally, C.; Viappiani, C.; Nonell, S.; Bonsfills, M. A.; Abbruzzetti, S. – Il Nuovo Cimento, 44:4-5(2021). [10.1393/ncc/i2021-21122-6]
  3. Unusually fast bis-histidyl coordination in a plant hemoglobin / Abbruzzetti, S.; Barker, A. J.; Villar, I.; Perez-Rontome, C.; Bruno, S.; Cerullo, G.; Viappiani, C.; Becana, M. - J. Mol. Sci., 22:5(2021), pp. 1-13. [10.3390/ijms22052740]
  4. Nanoscale Mapping of Recombinant Viral Proteins: From Cells to Virus-Like Particles / Arista-Romero, M.; Delcanale, P.; Pujals, S.; Albertazzi, L.. - ACS Photonics  (2021). [10.1021/acsphotonics.1c01154]
  5. Correlating Super-Resolution Microscopy and Transmission Electron Microscopy Reveals Multiparametric Heterogeneity in Nanoparticles / Andrian, T.; Delcanale, P.; Pujals, S.; Albertazzi, L. - Nano Letters, 21:12(2021), pp. 5360-5368. [10.1021/acs.nanolett.1c01666]
  6. Mapping the role of aromatic amino acids within a blue-light sensing LOV domain / Ding, Y.; Zhao, Z.; Matysik, J.; Gartner, W.; Losi, A. – Physical Chemistry Chemical Physics, 23:31(2021), pp. 16767-16775. [10.1039/d1cp02217b]
  7. The adjuvant activity of two urea derivatives on cytokinins: an example of serendipitous dual effect / Brunoni, F.; Rolli, E.; Polverini, E.; Spichal, L.; Ricci, A. -  Plant Growth Regul, 95(2021), pp. 169-190. [10.1007/s10725-021-00735-3]
  8. Reversible processes in collagen dehydration: A molecular dynamics study / Leo, L.; Bridelli, M. G.; Polverini, E. - Archives of Biochemistry and Biophysics, 714(2021), p. 109079.109079. [10.1016/j.abb.2021.109079]
  9. Mycobacterial and human ferrous nitrobindins: Spectroscopic and reactivity properties / De Simone, G.; Di Masi, A.; Pesce, A.; Bolognesi, M.; Ciaccio, C.; Tognaccini, L.; Smulevich, G.; Abbruzzetti, S.; Viappiani, C.; Bruno, S.; Della Monaca, S.; Pietraforte, D.; Fattibene, P.; Coletta, M.; Ascenzi, P. – J. Mol. Sci., 22:4(2021), pp. 1-27. [10.3390/ijms22041674]

 

  1. Photosensitizing proteins for antibacterial photodynamic inactivation / Hally, Cormac; Delcanale, Pietro; Nonell, Santi; Viappiani, Cristiano; Abbruzzetti, Stefania. - TRANSLATIONAL BIOPHOTONICS.  - (2020), p. e201900031. [10.1002/tbio.201900031]
  2. Tetramethylbenzidine: An Acoustogenic Photoacoustic Probe for Reactive Oxygen Species Detection / Bresolí-Obach, Roger; Frattini, Marcello; Abbruzzetti, Stefania; Viappiani, Cristiano; Agut, Montserrat; Nonell, Santi. –SENSORS. - 20:(2020), p. 5952. [10.3390/s20205952]
  3. Mycobacterial and Human Nitrobindins: Structure and Function / De Simone, Giovanna; di Masi, Alessandra; Vita, Gian Marco; Polticelli, Fabio; Pesce, Alessandra; Nardini, Marco; Bolognesi, Martino; Ciaccio, Chiara; Coletta, Massimo; Turilli, Emily Samuela; Fasano, Mauro; Tognaccini, Lorenzo; Smulevich, Giulietta; Abbruzzetti, Stefania; Viappiani, Cristiano; Bruno, Stefano; Ascenzi, Paolo. - ANTIOXIDANTS & REDOX SIGNALING. - 33:4(2020), pp. 229-246. [10.1089/ars.2019.7874]
  4. A Plant Gene Encoding One-Heme and Two-Heme Hemoglobins With Extreme Reactivities Toward Diatomic Gases and Nitrite / Villar, Irene; Larrainzar, Estíbaliz; Milazzo, Lisa; Pérez-Rontomé, Carmen; Rubio, Maria C.; Smulevich, Giulietta; Martínez, Jesús I.; Wilson, Michael T.; Reeder, Brandon; Huertas, Raul; Abbruzzetti, Stefania; Udvardi, Michael; Becana, Manuel. - FRONTIERS IN PLANT SCIENCE. - 11(2020), p. 600336. [10.3389/fpls.2020.600336]
  5. Photodynamic action of Hypericum perforatum hydrophilic extract against Staphylococcus aureus / Delcanale, Pietro; Hally, Cormac; Nonell, Santi; Bonardi, Silvia; Viappiani, Cristiano; Abbruzzetti, Stefania. - PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES. -905X. - 19:(2020), pp. 324-331. [10.1039/c9pp00428a]
  6. Tetramethylbenzidine: An Acoustogenic Photoacoustic Probe for Reactive Oxygen Species Detection / Bresolí-Obach, Roger; Frattini, Marcello; Abbruzzetti, Stefania; Viappiani, Cristiano; Agut, Montserrat; Nonell, Santi. - SENSORS. - 20:(2020), p. 5952. [10.3390/s20205952]
  7. Aptamers with Tunable Affinity Enable Single-Molecule Tracking and Localization of Membrane Receptors on Living Cancer Cells / Delcanale, P.; Porciani, D.; Pujals, S.; Jurkevich, A.; Chetrusca, A.; Tawiah, K. D.; Burke, D. H.; Albertazzi, L.. - ANGEWANDTE CHEMIE. INTERNATIONAL EDITION. - 59:42(2020), pp. 18546-18555. [10.1002/anie.202004764]
  8. DNA-PAINT super-resolution imaging data of surface exposed active sites on particles / Delcanale, P.; Albertazzi, L. -  DATA IN BRIEF. - 30(2020), p. 105468. [10.1016/j.dib.2020.105468]
  9. The first molecular characterisation of blue- and red-light photoreceptors from Methylobacterium radiotolerans / Consiglieri, Eleonora; Xu, Qianzhao; Zhao, Kai-Hong; Gärtner, Wolfgang; Losi, Aba. - PHYSICAL CHEMISTRY CHEMICAL PHYSICS. - 22(2020), pp. 12434-12446. [10.1039/D0CP02014A]
  10. Interplay among the "flipping" glutamine, a conserved phenylalanine, water and hydrogen bonds within a blue-light sensing LOV domain / Polverini, Eugenia; Schackert, Florian Karl; Losi, Aba. - PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES. - 19(2020), pp. 892-904. [10.1039/d0pp00082e]
  11. Conformational Flexibility Drives Cold Adaptation in Pseudoalteromonas haloplanktis TAC125 Globins / Giordano, D.; Boubeta, F. M.; Di Prisco, G.; Estrin, D. A.; Smulevich, G.; Viappiani, C.; Verde, C. - ANTIOXIDANTS & REDOX SIGNALING. - 32:6(2020), pp. 396-411. [10.1089/ars.2019.7887]
  12. Structural and functional properties of Antarctic fish cytoglobins-1: cold-reactivity in multi-ligand reactions / Giordano, Daniela; Pesce, Alessandra; Vermeylen, Stijn; Abbruzzetti, Stefania; Nardini, Marco; Marchesani, Francesco; Berghmans, Herald; Seira, Constantí; Bruno, Stefano; Javier Luque, F.; di Prisco, Guido; Ascenzi, Paolo; Dewilde, Sylvia; Bolognesi, Martino; Viappiani, Cristiano; Verde, Cinzia. - COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL. - 18(2020), pp. 2132-2144. [10.1016/j.csbj.2020.08.007]
  13. A porphycene-gentamicin conjugate for enhanced photodynamic inactivation of bacteria / Nieves, Ingrid; Hally, Cormac; Viappiani, Cristiano; Agut, Montserrat; Nonell, Santi. - BIOORGANIC CHEMISTRY. - 97(2020), p. 103661. [10.1016/j.bioorg.2020.103661]

2019

  1. Hypericin - apomyoglobin an enhanced photosensitizer complex for the treatment of tumor cells / Bianchini, Paolo; Cozzolino, Marco; Oneto, Michele; Pesce, Luca; Pennacchietti, Francesca; Tognolini, Massimiliano; Giorgio, Carmine; Nonell, Santi; Cavanna, Luigi; Delcanale, Pietro; Abbruzzetti, Stefania; Diaspro, Alberto; Viappiani, Cristiano. – Biomacromolecules, 20(2019), pp. 2024-2033. [10.1021/acs.biomac.9b00222]
  2. Dynamics and efficiency of photoswitching in biliverdin-binding phytochromes / Consiglieri, Eleonora; Alexander, Gutt; Gartner, Wolfgang; Luiz, Schubert; Viappiani, Cristiano; Abbruzzetti, Stefania; Losi, Aba. - Photochem Photobiol Sci, 18:(2019), pp. 2484-2496. [10.1039/c9pp00264b]
  3. Enhanced photosensitizing properties of protein bound curcumin / Cozzolino, Marco; Delcanale, Pietro; Montali, Chiara; Tognolini, Massimiliano; Giorgio, Carmine; Corrado, Miriam; Cavanna, Luigi; Bianchini, Paolo; Diaspro, Alberto; Abbruzzetti, Stefania; Viappiani, Cristiano. - Life Sciences (2019), p. 116710. [10.1016/j.lfs.2019.116710]
  4. More than a Confinement: “Soft” and “Hard” Enzyme Entrapment Modulates Biological Catalyst Function / Cottone, Grazia; Giuffrida, Sergio; Bettati, Stefano; Bruno, Stefano; Campanini, Barbara; Marchetti, Marialaura; Abbruzzetti, Stefania; Viappiani, Cristiano; Cupane, Antonio; Mozzarelli, Andrea; Ronda, Luca. - Catalysts , 9:12(2019), pp. 1024.1-1024.29. [10.3390/catal9121024]
  5. Apomyoglobin is an efficient carrier for zinc phthalocyanine in photodynamic therapy of tumors / Cozzolino, Marco; Pesce, Luca; Pezzuoli, Denise; Montali, Chiara; Brancaleon, Lorenzo; Cavanna, Luigi; Abbruzzetti, Stefania; Diaspro, Alberto; Bianchini, Paolo; Viappiani, Cristiano. – Biophysical Chemistry, 253(2019), pp. 254-262. [10.1016/j.bpc.2019.106228]
  6. Super-resolution microscopy as a powerful tool to study complex synthetic materials / Pujals, S.; Feiner-Gracia, N.; Delcanale, P.; Voets, I.; Albertazzi, L. - Nat Rev Chem, 3:2(2019), pp. 68-84. [10.1038/s41570-018-0070-2]
  7. MAS NMR on a Red/Far-Red Photochromic Cyanobacteriochrome All2699 from Nostoc / Xu, Qian-Zhao; Bielytskyi, Pavlo; Otis, James; Lang, Christina; Hughes, Jon; Zhao, Kai-Hong; Losi, Aba; Gartner, Wolfgang; Song, Chen.. - J. Mol. Sci., 20:15(2019), p. 3656. [10.3390/ijms20153656]
  8. Insight on collagen self-assembly mechanisms by coupling molecular dynamics and UV spectroscopy techniques / Leo, L.; Bridelli, M. G.; Polverini, E. - Biophysical Chemistry, 253(2019), p. 106224. [10.1016/j.bpc.2019.106224]

2018

  1. Menozzi, I.; Polverini, E.; Berni, R. Archives of Biochemistry and Biophysics 2018, 645, 107.
  2. Sala, A.; Cabassi, C. S.; Santospirito, D.; Polverini, E.; Flisi, S.; Cavirani, S.; Taddei, S. PLoS ONE 2018, 13
  3. Pezzuoli, D.; Cozzolino, M.; Montali, C.; Brancaleon, L.; Bianchini, P.; Zantedeschi, M.; Bonardi, S.; Viappiani, C.; Abbruzzetti, S. Food Control 2018, 94, 254.
  4. Delcanale, P.; Galstyan, A.; Daniliuc, C. G.; Grecco, H. E.; Abbruzzetti, S.; Faust, A.; Viappiani, C.; Strassert, C. A. ACS Applied Materials & Interfaces 2018, 10, 24361.
  5. Boubeta, F. M.; Boechi, L.; Estrin, D.; Patrizi, B.; Di Donato, M.; Iagatti, A.; Giordano, D.; Verde, C.; Bruno, S.; Abbruzzetti, S.; Viappiani, C. Journal of Physical Chemistry B 2018, 122, 11649.
  6. Abbruzzetti, S.; Allegri, A.; Bidon-Chanal, A.; Ogata, H.; Soavi, G.; Cerullo, G.; Bruno, S.; Montali, C.; Luque, F. J.; Viappiani, C. Scientific Reports 2018, 8, 10855.
  7. A. Losi, K. Gardner, A. Moeglich, Chemical Reviews, 2018, 118, 10659
  8. W.-L.Ding⁠, Y.-N. Hou⁠, Z.-Z. Tan⁠, S.-P. Jiang⁠, D. Miao, A. Losi⁠, W. Gaertner⁠, H. Scheer⁠, K.-H. Zhao, BBA - Molecular Cell Research, 2018, 1865, 1649 -1656

2017

  1. Ambrico, M.; Ambrico, P. F.; Ligonzo, T.; Cardone, A.; Bridelli, M. G.; Casamassima, G.; Manini, P.; D'Ischia, M. Physical Chemistry Chemical Physics 2017, 19, 9432.
  2. Calvo-Begueria, L.; Cuypers, B.; Van Doorslaer, S.; Abbruzzetti, S.; Bruno, S.; Berghmans, H.; Dewilde, S.; Ramos, J.; Viappiani, C. O.; Becana, M. Frontiers in Plant Science 2017, 8.
  3. Delcanale, P.; Rodríguez-Amigo, B.; Juárez-Jiménez, J.; Luque, F. J.; Abbruzzetti, S.; Agut, M.; Nonell, S.; Viappiani, C. Journal of Materials Chemistry B 2017, 5, 1633.
  4. Ferrari, E.; Capucciati, A.; Prada, I.; Zucca, F. A.; D’Arrigo, G.; Pontiroli, D.; Bridelli, M. G.; Sturini, M.; Bubacco, L.; Monzani, E.; Verderio, C.; Zecca, L.; Casella, L. ACS Chemical Neuroscience 2017, 8, 501.
  5. Losi, A.; Bonomi, H. R.; Michael, N.; Tang, K.; Zhao, K. H. Photochemistry and Photobiology 2017, 93, 733.
  6. Menozzi, I.; Vallese, F.; Polverini, E.; Folli, C.; Berni, R.; Zanotti, G. Journal of Structural Biology 2017, 197, 330.
  7. Russo, R.; Giordano, D.; Paredi, G.; Marchesani, F.; Milazzo, L.; Altomonte, G.; Del Canale, P.; Abbruzzetti, S.; Ascenzi, P.; Di Prisco, G.; Viappiani, C.; Fago, A.; Bruno, S.; Smulevich, G.; Verde, C. PLoS ONE 2017, 12.
  8. Simon, J.; Losi, A.; Zhao, K. H.; Gärtner, W. Photochemistry and Photobiology 2017, 93, 1057.

2016

  1. Cugini, F.; Porcari, G.; Viappiani, C.; Caron, L.; Dos Santos, A. O.; Cardoso, L. P.; Passamani, E. C.; Proveti, J. R. C.; Gama, S.; Brück, E.; Solzi, M. Applied Physics Letters 2016, 108.
  2. Delcanale, P.; Montali, C.; Rodríguez-Amigo, B.; Abbruzzetti, S.; Bruno, S.; Bianchini, P.; Diaspro, A.; Agut, M.; Nonell, S.; Viappiani, C. Journal of Agricultural and Food Chemistry 2016, 64, 8633.
  3. Galstyan, A.; Block, D.; Niemann, S.; Grüner, M. C.; Abbruzzetti, S.; Oneto, M.; Daniliuc, C. G.; Hermann, S.; Viappiani, C.; Schäfers, M.; Löffler, B.; Strassert, C. A.; Andreas, A. Chemistry - A European Journal 2016, 22, 9051.
  4. Santiago-Ruiz S.; Polverini E.; Manjarrez J.; Espinoza K.A.; Reynoso E.; Rivero I.A. Annals of Medicinal Chemistry and Research 2016, 2, 1016.

2015

  1. Tilleman, L.; Abbruzzetti, S.; Ciaccio, C.; De Sanctis, G.; Nardini, M.; Pesce, A.; Desmet, F.; Moens, L.; Van Doorslaer, S.; Bruno, S.; Bolognesi, M.; Ascenzi, P.; Coletta, M.; Viappiani, C.; Dewilde, S., Structural Bases for the Regulation of CO Binding in the Archaeal Protoglobin from Methanosarcina acetivorans. PLoS ONE 2015, 10, (6), e0125959.
  2. Ronda, L.; Bruno, S.; Campanini, B.; Mozzarelli, A.; Abbruzzetti, S.; Viappiani, C.; Cupane, A.; Levantino, M.; Bettati, S., Immobilization of Proteins in Silica Gel: Biochemical and Biophysical Properties. Current Organic Chemistry 2015,19, 1653-1668.
  3. Rodríguez-Amigo, B.; Delcanale, P.; Rotger, G.; Juárez-Jiménez, J.; Abbruzzetti, S.; Summer, A.; Agut, M.; Luque, F. J.; Nonell, S.; Viappiani, C., The complex of hypericin with b-lactoglobulin has antimicrobial activity with perspective applications in dairy industry. Journal of Dairy Science 2015, 98, 89–94.
  4. Pennacchietti, F.; Losi, A.; Xu, X.; Zhao, K.; Gärtner, W.; Viappiani, C.; Zanacchi, F. C.; Diaspro, A.; Abbruzzetti, S., Photochromic conversion in a red/green cyanobacteriochrome from Synechocystis PCC6803: quantum yields in solution and photoswitching dynamics in living E.coli cells. Photochemical & Photobiological Sciences 2015, 14, 229-237.
  5. Knipp, M.; Ogata, H.; Soavi, G.; Cerullo, G.; Allegri, A.; Abbruzzetti, S.; Bruno, S.; Viappiani, C.; Bidon-Chanal, A.; Luque, F. J., Structure and dynamics of the membrane attaching nitric oxide transporter nitrophorin 7 [v1; ref status: indexed]. F100 Research 2015, 4, 45.
  6. Henry, Eric R.; Mozzarelli, A.; Viappiani, C.; Abbruzzetti, S.; Bettati, S.; Ronda, L.; Bruno, S.; Eaton, William A., Experiments on Hemoglobin in Single Crystals and Silica Gels Distinguish among Allosteric Models. Biophysical journal 2015, 109, (6), 1264-1272.
  7. Delcanale, P.; Pennacchietti, F.; Maestrini, G.; Rodríguez-Amigo, B.; Bianchini, P.; Diaspro, A.; Iagatti, A.; Patrizi, B.; Foggi, P.; Agut, M.; Nonell, S.; Abbruzzetti, S.; Viappiani, C., Subdiffraction localization of a nanostructured photosensitizer in bacterial cells. Scientific Reports 2015, 5, 15564.
  8. Decaneto, E.; Abbruzzetti, S.; Heise, I.; Lubitz, W.; Viappiani, C.; Knipp, M., A caged substrate peptide for matrix metalloproteinases. Photochemical & Photobiological Sciences 2015, 14, (2), 300-307.
  9. Coppola, D.; Giordano, D.; Abbruzzetti, S.; Marchesani, F.; Balestrieri, M.; di Prisco, G.; Viappiani, C.; Bruno, S.; Verde, C., Functional characterisation of the haemoglobins of the migratory notothenioid fish Dissostichus eleginoides. Hydrobiologia 2015, 761, (1), 315-333.
  10. Boron, I.; Capece, L.; Pennacchietti, F.; Wetzler, D. E.; Bruno, S.; Abbruzzetti, S.; Chisari, L.; Luque, F. J.; Viappiani, C.; Marti, M. A.; Estrin, D. A.; Nadra, A., Engineered chimeras reveal the structural basis of hexacoordination in globins: A case study of neuroglobin and myoglobin. Biochimica et Biophysica Acta (BBA) - General Subjects 2015,1850, 169–177
  11. Ricci, A.; Dramis, L.; Shah, R.; Gärtner, W.; Losi, A. Visualizing the relevance of bacterial blue- and red-light receptors during plant-pathogen interaction Environmental Microbiology Reports 2015, 7, 795-802.
  12. Losi, A.; Abbruzzetti, S. Photofunctional proteins: How nature keeps the laboratories updated about light and life Photochemical and Photobiological Sciences 2015, 14, 198-199.
  13. Losi, A.; Mandalari, C.; Gärtner, W. The Evolution and Functional Role of Flavin-based Prokaryotic Photoreceptors Photochemistry and Photobiology 2015, 91, 1021-1031.
  14. Kraiselburd, I.; Gutt, A.; Losi, A.; Gärtner, W.; Orellano, E. G. Functional Characterization of a LOV-Histidine Kinase Photoreceptor from Xanthomonas citri subsp. citri Photochemistry and Photobiology2015, 91, 1123-1132.
  15. Bisceglie, F.; Musiari, A.; Pinelli, S.; Alinovi, R.; Menozzi, I.; Polverini, E.; Tarasconi, P.; Tavone, M.; Pelosi, G. Quinoline-2-carboxaldehyde thiosemicarbazones and their Cu(II) and Ni(II) complexes as topoisomerase IIa inhibitors Journal of Inorganic Biochemistry 2015, 152, 10-19
  16. Boron, I.; Capece, L.; Pennacchietti, F.; Wetzler, D. E.; Bruno, S.; Abbruzzetti, S.; Chisari, L.; Luque, F. J.; Viappiani, C.; Marti, M. A.; Estrin, D. A.; Nadra, A. D. Biochimica et Biophysica Acta - General Subjects 2015, 1850, 169.
  17. Coppola, D.; Giordano, D.; Abbruzzetti, S.; Marchesani, F.; Balestrieri, M.; di Prisco, G.; Viappiani, C.; Bruno, S.; Verde, C. Hydrobiologia 2015, 761, 315.
  18. Decaneto, E.; Abbruzzetti, S.; Heise, I.; Lubitz, W.; Viappiani, C.; Knipp, M. Photochemical and Photobiological Sciences 2015, 14, 300.
  19. Delcanale, P.; Pennacchietti, F.; Maestrini, G.; Rodríguez-Amigo, B.; Bianchini, P.; Diaspro, A.; Iagatti, A.; Patrizi, B.; Foggi, P.; Agut, M.; Nonell, S.; Abbruzzetti, S.; Viappiani, C. Scientific Reports 2015, 5.
  20. Henry, E. R.; Mozzarelli, A.; Viappiani, C.; Abbruzzetti, S.; Bettati, S.; Ronda, L.; Bruno, S.; Eaton, W. A. Biophysical Journal 2015, 109, 1264.
  21. Knipp, M.; Ogata, H.; Soavi, G.; Cerullo, G.; Allegri, A.; Abbruzzetti, S.; Bruno, S.; Viappiani, C.; Bidon-Chanal, A.; Luque, F. J. F1000Research 2015, 4.
  22. Kraiselburd, I.; Gutt, A.; Losi, A.; Gärtner, W.; Orellano, E. G. Photochemistry and Photobiology 2015, 91, 1123.
  23. Losi, A.; Abbruzzetti, S. Photochemical and Photobiological Sciences 2015, 14, 198.
  24. Losi, A.; Mandalari, C.; Gärtner, W. Photochemistry and Photobiology 2015, 91, 1021.
  25. Pennacchietti, F.; Losi, A.; Xu, X. L.; Zhao, K. H.; Gärtner, W.; Viappiani, C.; Cella, F.; Diaspro, A.; Abbruzzetti, S. Photochemical and Photobiological Sciences 2015, 14, 229.
  26. Planas, O.; Boix-Garriga, E.; Rodríguez-Amigo, B.; Torra, J.; Bresolí-Obach, R.; Flors, C.; Viappiani, C.; Agut, M.; Ruiz-González, R.; Nonell, S. In Photochemistry 2015; Vol. 42, p 233.
  27. Ricci, A.; Dramis, L.; Shah, R.; Gärtner, W.; Losi, A. Environmental Microbiology Reports 2015, 7, 795.
  28. Ronda, L.; Bruno, S.; Campanini, B.; Mozzarellib, A.; Abbruzzetti, S.; Viappiani, C.; Cupane, A.; Levantino, M.; Bettati, S. Current Organic Chemistry 2015, 19, 1653.

2014

  1. Viappiani C, Abbruzzetti S, Ronda L, Bettati S, Henry ER, Mozzarelli A, Eaton WA (2014) Experimental basis for a new allosteric model for multisubunit proteins. Proc Natl Acad Sci USA 111: 12758-12763
  2. Planas O, Boix-Garriga E, Rodríguez-Amigo T, J.B., Bresolí-Obach R, Flors C, Viappiani C, Agut M, Ruiz-González R, Nonell S (2014) Newest approaches to singlet oxygen photosensitisation in biological media. In: Fasani AAaE, editor. Photochemistry. London: The Royal Society of Chemistry.
  3. Pennacchietti F, Abbruzzetti S, Losi A, Mandalari C, Bedotti R, Viappiani C, Zanacchi FC, Diaspro A, Gärtner W (2014) The dark recovery rate in the photocycle of the bacterial photoreceptor YtvA is affected by the cellular environment and by hydration. PLoS ONE 9: e107489.
  4. Bustamante JP, Abbruzzetti S, Marcelli A, Gauto D, Boechi L, Bonamore A, Boffi A, Bruno S, Feis A, Foggi P, Estrin DA, Viappiani C (2014) Ligand Uptake Modulation by Internal Water Molecules and Hydrophobic Cavities in Hemoglobins. J Phys Chem B 118: 1234–1245
  5. Pennacchietti, F., Losi, A., Xu, X., Zhao, K., Gärtner, W., Viappiani, C., Zanacchi, F. C., Diaspro, A., and Abbruzzetti, S. (2014) Photochromic conversion in a red/green cyanobacteriochrome from Synechocystis PCC6803: quantum yields in solution and photoswitching dynamics in living E.coli cells, Photochemical & Photobiological Sciences in press.
  6. Marchi L, Polverini E, Degola F, Baruffini E, Restivo FM (2014) Glutamate dehydrogenase isoenzyme 3 (GDH3) of Arabidopsis thaliana is less thermostable than GDH1 and GDH2 isoenzymes. Plant Physiology and Biochemistry 83: 225-231.
  7. Chen Zh, Raffelberg S, Losi A, Schaap P, Gärtner W (2014) A cyanobacterial light activated adenylyl cyclase partially restores development of a Dictyostelium discoideum, adenylyl cyclase a null mutant. Journal of Biotechnology. in press

 2013

  1.  Marchi L, Degola F, Polverini E, Terca-Laforgue T, Dubois F, Hirel B, Restivo FM (2013) Glutamate dehydrogenase isoenzyme 3 (GDH3) of Arabidopsis thaliana is regulated by a combined effect of nitrogen and cytokinin. Plant Physiology and Biochemistry 73: 368-374.
  2. Vassall KA, Bessonov K, De Avila M, Polverini E, Harauz G (2013) The Effects of Threonine Phosphorylation on the Stability and Dynamics of the Central Molecular Switch Region of 18.5-kDa Myelin Basic Protein. PLoS ONE 8.
  3. Scaltriti E, Polverini E, Grolli S, Eufemi E, Moineau S, Cambillau C, Ramoni R (2013) The DNA binding mechanism of a SSB protein from Lactococcus lactis siphophage p2. Biochimica et Biophysica Acta - Proteins and Proteomics 1834: 1070-1076.
  4. Raffelberg S, Gutt A, Gärtner W, Mandalari C, Abbruzzetti S, Viappiani C, Losi A (2013) The amino acids surrounding the flavin 7a-methyl group determine the UVA spectral features of a LOV protein. Biological Chemistry 394: 1517-1528.
  5. Raffelberg S, Wang L, Gao S, Losi A, Gärtner W, Nagel G (2013) A LOV-domain-mediated blue-light-activated adenylate (adenylyl) cyclase from the cyanobacterium Microcoleus chthonoplastes PCC 7420. Biochemical Journal 455: 359-365.
  6. Engelhard C, Raffelberg S, Tang Y, Diensthuber RP, Möglich A, Losi A, Gärtner W, Bittl R (2013) A structural model for the full-length blue light-sensing protein YtvA from Bacillus subtilis, based on EPR spectroscopy. Photochemical and Photobiological Sciences 12: 1855-1863.
  7. Losi A (2013) Blue-light photoreceptors: From activation to advanced applications. Photochemical and Photobiological Sciences 12: 1124.
  8. Mandalari C, Losi A, Gärtner W (2013) Distance-tree analysis, distribution and co-presence of bilin- and flavin-binding prokaryotic photoreceptors for visible light. Photochemical and Photobiological Sciences 12: 1144-1157.
  9. Losi A, Gärtner W, Raffelberg S, Cella Zanacchi F, Bianchini P, Diaspro A, Mandalari C, Abbruzzetti S, Viappiani C (2013) A photochromic bacterial photoreceptor with potential for super-resolution microscopy. Photochemical and Photobiological Sciences 12: 231-235.
  10. Bridelli MG, Capelletti R, Mora C (2013) Structural features and functional properties of water in model DMPC membranes: Thermally stimulated depolarization currents (TSDCs) and Fourier transform infrared (FTIR) studies. Journal of Physics D: Applied Physics 46.
  11. Abbruzzetti S, Spyrakis F, Bidon-Chanal A, Luque FJ, Viappiani C (2013) Ligand migration through hemeprotein cavities: insights from laser flash photolysis and molecular dynamics simulations. Physical Chemistry Chemical Physics 15: 10686-10701.
  12. Comas-Barceló J, Rodríguez-Amigo B, Abbruzzetti S, Rey-Puech Pd, Agut M, Nonell S, Viappiani C (2013) A self-assembled nanostructured material with photosensitising properties. RSC Advances 3: 17874-17879.
  13. Gabba M, Abbruzzetti S, Spyrakis F, Bruno S, Mozzarelli A, Luque FJ, Viappiani C, Cozzini P, Nardini M, Germani F, Bolognesi M, Moens L, Dewilde S (2013) CO rebinding kinetics and molecular dynamics simulations highlight dynamic regulation of internal cavities in human cytoglobin. PLoS ONE 8: e49770.
  14. Gensch T, Viappiani C, Braslavsky SE (2013) Laser Induced Optoacoustic Spectroscopy. In: Reedijk J, editor. Elsevier Reference Module in Chemistry, Molecular Sciences and Chemical Engineering. Waltham, MA: Elsevier.
  15. Losi A, Gärtner W, Raffelberg S, Zanacchi FC, Bianchini P, Diaspro A, Mandalari C, Abbruzzetti S, Viappiani C (2013) A photochromic bacterial photoreceptor with potential for super-resolution microscopy. Photochemical and Photobiological Sciences 12: 231–235.
  16. Oliveira A, Allegri A, Bidon-Chanal A, Knipp M, Roitberg AE, Abbruzzetti S, Viappiani C, Luque FJ (2013) Kinetics and computational studies of ligand migration in nitrophorin 7 and its D1-3 mutant. Biochimica et Biophysica Acta - Proteins and Proteomics 1834: 1711-1721.
  17. Pesce A, Tilleman L, Donné J, Aste E, Ascenzi P, Ciaccio C, Coletta M, Moens L, Viappiani C, Dewilde S, Bolognesi M, Nardini M (2013) Structure and haem-distal site plasticity in ferric Methanosarcina acetivorans protoglobin PLoS ONE 8: e66144.
  18. Raffelberg S, Gutt A, Gärtner W, Mandalari C, Abbruzzetti S, Viappiani C, Losi A (2013) The amino acids surrounding the flavin 7a-methyl group determine the UVA spectral features of a LOV protein. Biological Chemistry 394: 1517–1528.
  19. Spyrakis F, Lucas F, Bidon-Chanal A, Viappiani C, Guallar V, Luque FJ (2013) Comparative analysis of inner cavities and ligand migration in non-symbiotic AHb1 and AHb2. Biochimica et Biophysica Acta - Proteins and Proteomics 1834: 1957-1967.

 2012

  1. Ahmed MAM, De Avila M, Polverini E, Bessonov K, Bamm VV, Harauz G (2012) Solution nuclear magnetic resonance structure and molecular dynamics simulations of a murine 18.5 kDa myelin basic protein segment (S72-S107) in association with dodecylphosphocholine micelles. Biochemistry 51: 7475-7487.
  2. Stehling EG, Sforza ML, Zanchin NIT, Oyama S, Pignatelli A, Belluzzi O, Polverini E, Corsini R, Spisni A, Pertinhez TA (2012) Looking over toxin-K + channel interactions. clues from the structural and functional characterization of α-KTx Toxin Tc32, a Kv1.3 Channel Blocker. Biochemistry 51: 1885-1894.
  3. Kraiselburd I, Alet AI, Tondo ML, Petrocelli S, Daurelio LD, Monzon J, Ruiz OA, Losi A, Orellano EG (2012) A LOV protein modulates the physiological attributes of xanthomonas axonopodis pv. citri relevant for host plant colonization. PLoS ONE 7.
  4. Losi A, Gärtner W (2012) The evolution of flavin-binding photoreceptors: An ancient chromophore serving trendy blue-light sensors. Annual Review of Plant Biology. pp. 49-72.
  5. Pathak GP, Losi A, Gärtner W (2012) Metagenome-based screening reveals worldwide distribution of LOV-domain proteins. Photochemistry and Photobiology 88: 107-118.
  6. Abbruzzetti S, He C, Ogata H, Bruno S, Viappiani C, Knipp M (2012) Heterogeneous Kinetics of the Carbon Monoxide Association and Dissociation Reaction to Nitrophorin 4 and 7 Coincide with Structural Heterogeneity of the Gate-Loop. Journal of the American Chemical Society 134: 9986–9998.
  7. Abbruzzetti S, Tilleman L, Bruno S, Viappiani C, Desmet F, Doorslaer SV, Coletta M, Ciaccio C, Ascenzi P, Nardini M, Bolognesi M, Moens L, Dewilde S (2012) Ligation tunes protein reactivity in an ancient haemoglobin: kinetic evidence for an allosteric mechanism in Methanosarcina acetivorans protoglobin. PLoS ONE 7: e33614.
  8. Coppola D, Abbruzzetti S, Nicoletti F, Merlino A, Gambacurta A, Giordano D, Howes BD, DeSanctis G, Vitagliano L, Bruno S, G.diPrisco, Mazzarella L, Smulevich G, Coletta M, Viappiani C, Vergara A, Verde C (2012) ATP regulation of the ligand-binding properties in temperate and cold-adapted haemoglobins. X-ray structure and ligand-binding kinetics in the sub-Antarctic fish Eleginops maclovinus. MOLECULAR BIOSYSTEMS 8: 3295-3304.
  9. Giordano D, Boron I, Abbruzzetti S, VanLeuven W, Nicoletti F, Forti F, Bruno S, Cheng CHC, Moens L, diPrisco G, Nadra A, Estrin D, Smulevich G, Dewilde S, Viappiani C, Verde C (2012) Biophysical characterisation of neuroglobin of the icefish, a natural knockout for hemoglobin and myoglobin. Comparison with human neuroglobin. PLoS ONE 7: e44508.
  10. Knipp M, Taing J, He C, Viappiani C (2012) A caged cyanide. Photochemical and Photobiological Sciences 11: 620-622.
  11. Losi A, Viappiani C (2012) Flavin Mononucleotide-Binding Fluorescent Proteins. In: Roberts GCK, editor. Encyclopedia of Biophysics. Berlin Heidelberg: Springer-Verlag
  12. Marcelli A, Abbruzzetti S, Bustamante JP, Feis A, Bonamore A, Boffi A, Gellini C, Salvi PR, Estrin DA, Bruno S, Viappiani C, Foggi P (2012) Following Ligand Migration Pathways from Picoseconds to Milliseconds in Type II Truncated Hemoglobin from Thermobifida fusca. PLoS ONE 7: e39884.
  13. Nack M, Radu l, Schultz BJ, Resler T, Schlesinger R, Bondar AN, Val Cd, Abbruzzetti S, Viappiani C, Bamann C, Bamberg E, Heberle J (2012) Kinetics of Proton Release and Uptake by Channelrhodopsin-2. FEBS Letters 586: 1344–1348.

2011

  1. Polverini E, Lardi P, Mazzini A, Sorbi RT, Virna C, Ramoni R, Favilla R (2011) Characterization of a deswapped triple mutant bovine odorant binding protein. International Journal of Molecular Sciences 12: 2294-2314.
  2. Polverini E, Coll EP, Tieleman DP, Harauz G (2011) Conformational choreography of a molecular switch region in myelin basic protein-Molecular dynamics shows induced folding and secondary structure type conversion upon threonyl phosphorylation in both aqueous and membrane-associated environments. Biochimica et Biophysica Acta - Biomembranes 1808: 674-683.
  3. Losi A, Gärtner W (2011) Old chromophores, new photoactivation paradigms, trendy applications: Flavins in blue light-sensing photoreceptors. Photochemistry and Photobiology 87: 491-510.
  4. Raffelberg S, Mansurova M, Gärtner W, Losi A (2011) Modulation of the photocycle of a LOV domain photoreceptor by the hydrogen-bonding network. Journal of the American Chemical Society 133: 5346-5356.
  5. Stierl M, Stumpf P, Udwari D, Gueta R, Hagedorn R, Losi A, Gärtner W, Petereit L, Efetova M, Schwarzel M, Oertner TG, Nagel G, Hegemann P (2011) Light modulation of cellular cAMP by a small bacterial photoactivated adenylyl cyclase, bPAC, of the soil bacterium Beggiatoa. Journal of Biological Chemistry 286: 1181-1188.
  6. Abbruzzetti S, Faggiano S, Spyrakis F, Bruno S, Mozzarelli A, Astegno A, Dominici P, Viappiani C (2011) Oxygen and Nitric Oxide Rebinding Kinetics in Nonsymbiotic Hemoglobin AHb1 from Arabidopsis thaliana. IUBMB Life 63: 1094–1100.
  7. Abbruzzetti S, Viappiani C (2011) Volume Changes Associated with Solute–Solvent Reorganization Following Photoinduced Proton Transfer in Aqueous Solutions of 6-Methoxyquinoline. In: Han KL, Zhao GJ, editors. Hydrogen Bonding and Transfer in the Excited State. Chichester: John Wiley & Sons, Ltd. pp. 797-803.
  8. Bettati S, Luque FJ, Viappiani C (2011) Protein dynamics: Experimental and computational approaches. Biochimica et Biophysica Acta - Proteins and Proteomics 1814: 913–915.
  9. Bisht NK, Abbruzzetti S, Uppal S, Bruno S, Spyrakis F, Mozzarelli A, Viappiani C, Kundu S (2011) Ligand migration and hexacoordination in type 1 non symbiotic rice hemoglobin. Biochimica et Biophysica Acta - Proteins and Proteomics 1814: 1042–1053.
  10. Bruno S, Ronda L, Abbruzzetti S, Viappiani C, Bettati S, Maji S, Mozzarelli A (2011) Protein encapsulation, conformations, and nanobiotools. In: Nalwa HS, editor. Encyclopedia of Nanoscience and Nanotechnology: American Scientific Publishers. pp. 481-517.
  11. Coppola D, Bruno S, Ronda L, Viappiani C, Abbruzzetti S, diPrisco G, Verde C, Mozzarelli A (2011) Low affinity PEGylated hemoglobin from Trematomus bernacchii, a model for hemoglobin-based blood substitutes. BMC Biochemistry 12: 66.
  12. Forti F, Boechi L, Bikiel D, Martí MA, Nardini M, Bolognesi M, Viappiani C, Estrin D, Luque FJ (2011) Ligand migration in Methanosarcina acetivorans protoglobin: effects of ligand binding and dimeric assembly. Journal of Physical Chemistry B 115: 13771–13780.
  13. Spyrakis F, Bruno S, Bidon-Chanal A, Luque FJ, Abbruzzetti S, Viappiani C, Dominici P, Mozzarelli A (2011) Oxygen binding to Arabidopsis thaliana AHb2 nonsymbiotic hemoglobin: evidence for a role in oxygen transport. IUBMB Life 63: 355–362.
  14. Spyrakis F, Faggiano S, Abbruzzetti S, Dominici P, Cacciatori E, Astegno A, Droghetti E, Feis A, Smulevich G, Bruno S, Mozzarelli A, Cozzini P, Viappiani C, Bidon-Chanal A, Luque FJ (2011) Histidine E7 dynamics modulates ligand exchange between distal pocket and solvent in AHb1 from Arabidopsis thaliana. Journal of Physical Chemistry B 115: 4138–4146.
  15. Spyrakis F, Luque FJ, Viappiani C (2011) Structural analysis in nonsymbiotic hemoglobins: what can we learn from inner cavities? Plant Science 181: 8-13.

 

2010

  1. Kursula P, Majava V, Polverini E, Mazzini A, Nanekar R, Knoll W, Peters J, Natali F, Baumgärtel P, Kursula I (2010) Structural and functional characterization of human peripheral nervous system myelin protein P2. PLoS ONE 5.
  2. Bedotti R, Bridelli MG, Capelletti R, Polverini E (2010) Thermally Stimulated Depolarization Currents (TSDC): A sensitive technique for analyzing protein structure. Spectroscopy 24: 297-301.
  3. Losi A, Viappiani C, Nonell S (2010) Photofunctional proteins: From understanding to engineering. Photochemical and Photobiological Sciences 9: 1285.
  4. Cao Z, Livoti E, Losi A, Gärtner W (2010) A blue light-inducible phosphodiesterase activity in the cyanobacterium synechococcus elongatus. Photochemistry and Photobiology 86: 606-611.
  5. Tang Y, Cao Z, Livoti E, Krauss U, Jaeger KE, Gärtner W, Losi A (2010) Interdomain signalling in the blue-light sensing and GTP-binding protein YtvA: A mutagenesis study uncovering the importance of specific protein sites. Photochemical and Photobiological Sciences 9: 47-56.
  6. Bridelli MG, Crippa PR (2010) Infrared and water sorption studies of the hydration structure and mechanism in natural and synthetic melanin. Journal of Physical Chemistry B 114: 9381-9390.
  7. Abbruzzetti S, Bizzarri R, Luin S, Nifosì R, Storti B, Viappiani C, Beltram F (2010) Photoswitching of E222Q GFP mutants: "concerted" mechanism of chromophore isomerization and protonation. Photochemical and Photobiological Sciences 9: 1307-1319.
  8. Bizzarri R, Serresi M, Cardarelli F, Abbruzzetti S, Campanini B, Viappiani C, Beltram F (2010) Single aminoacid replacement makes Aequorea victoria fluorescent proteins reversibly photoswitchable. Journal of the American Chemical Society 132: 85–95.
  9. Jiménez-Banzo A, Ragàs X, Abbruzzetti S, Viappiani C, Campanini B, Flors C, Nonell S (2010) Singlet oxygen photosensitisation by GFP mutants: Oxygen accessibility to the chromophore. Photochemical and Photobiological Sciences 9: 1336-1341.
  10. Losi A, Nonell S, Viappiani C (2010) Photofunctional proteins: from understanding to engineering. Photochemical and Photobiological Sciences 9: 1285-1285
  11. Nienhaus K, Dominici P, Astegno A, Abbruzzetti S, Viappiani C, Nienhaus GU (2010) Ligand migration and binding in non-symbiotic hemoglobins of Arabidopsis thaliana. Biochemistry 49: 7448–7458.

 

2009

  1. Homchaudhuri L, Polverini E, Gao W, Harauz G, Boggs JM (2009) Influence of membrane surface charge and post-translational modifications to myelin basic protein on its ability to tether the Fyn-SH3 domain to a membrane in vitro. Biochemistry 48: 2385-2393.
  2. Krauss U, Minh BQ, Losi A, Gärtner W, Eggert T, Von Haeseler A, Jaeger KE (2009) Distribution and phylogeny of light-oxygen-voltage-blue-light-signaling proteins in the three kingdoms of life. Journal of Bacteriology 191: 7234-7242.
  3. Jentzsch K, Wirtz A, Circolone F, Drepper T, Losi A, Gärtner W, Jaeger KE, Krauss U (2009) Mutual exchange of kinetic properties by extended mutagenesis in two short LOV domain proteins from Pseudomonas putida. Biochemistry 48: 10321-10333.
  4. Avila-Perez M, Vreede J, Tang Y, Bende O, Losi A, Gärtner W, Hellingwerf K (2009) In vivo mutational analysis of YtvA from bacillus subtilis. Mechanism of light activation of the general stress response. Journal of Biological Chemistry 284: 24958-24964.
  5. Ogata H, Cao Z, Losi A, Gärtner W (2009) Crystallization and preliminary X-ray analysis of the LOV domain of the blue-light receptor YtvA from Bacillus amyloliquefaciens FZB42. Acta Crystallographica Section F: Structural Biology and Crystallization Communications 65: 853-855.
  6. Abbruzzetti S, Faggiano S, Bruno S, Spyrakis F, Mozzarelli A, Dewilde S, Moens L, Viappiani C (2009) Ligand migration through the internal hydrophobic cavities in human neuroglobin. Proceedings of the National Academy of Science USA 106: 18984–18989.
  7. Bettati S, Viappiani C, Mozzarelli A (2009) Hemoglobin, an “evergreen” red protein. Biochimica et Biophysica Acta - Proteins and Proteomics 1794: 1317–1324.
  8. Caccia D, Ronda L, Frassi R, Perrella M, DelFavero E, Bruno S, Pioselli B, Abbruzzetti S, Viappiani C, Mozzarelli A (2009) PEGylation Promotes Hemoglobin Tetramer Dissociation. Bioconjugate Chemistry 20: 1356–1366.
  9. Faggiano S, Abbruzzetti S, Spyrakis F, Grandi E, Viappiani C, Bruno S, Mozzarelli A, Cozzini P, Astegno A, Dominici P, Brogioni S, Feis A, Smulevich G, Carrillo O, Schmidtke P, Bidon-Chanal A, Luque FJ (2009) Structural plasticity and functional implications of internal cavities in distal mutants of type 1 non-symbiotic hemoglobin AHb1 from Arabidopsis thaliana. Journal of Physical Chemistry B 113: 16028–16038.
  10. Storti B, Elisei F, Abbruzzetti S, Viappiani C, Latterini L (2009) One-Pot Synthesis of Gold Nanoshells with High Photon-to-Heat Conversion Efficiency. Journal of Physical Chemistry C 113: 7516–7521.
  11. Viappiani C, Abbruzzetti S, Vezzani G (2009) Photosensitivity of CO complexes with hemoglobins. Medicina Subacquea e Iperbarica: 16-18.

 

2008

  1. Musse AA, Polverini E, Raijmakers R, Harauz G (2008) Kinetics of human peptidylarginine deiminase 2 (hPAD2) - Reduction of Ca2+ dependence by phospholipids and assessment of proposed inhibition by paclitaxel side chains. Biochemistry and Cell Biology 86: 437-447.
  2. Polverini E, Rangaraj G, Libich DS, Boggs JM, Harauz G (2008) Binding of the proline-rich segment of myelin basic protein to SH3 domains: Spectroscopic, microarray, and modeling studies of ligand conformation and effects of posttranslational modifications. Biochemistry 47: 267-282.
  3. Losi A, Gärtner W (2008) Bacterial bilin- and flavin-binding photoreceptors. Photochemical and Photobiological Sciences 7: 1168-1178.
  4. Losi A, Gärtner W (2008) Shedding (blue) light on algal gene expression. Proceedings of the National Academy of Sciences of the United States of America 105: 7-8.
  5. Cao Z, Buttani V, Losi A, Gärtner W (2008) A blue light inducible two-component signal transduction system in the plant pathogen Pseudomonas syringae pv. tomato. Biophysical journal 94: 897-905.
  6. Bridelli MG, Capelletti R (2008) Hydration structure analysis of lysozyme amyloid fibrils by thermally stimulated depolarization currents (TSDC) technique. Spectroscopy 22: 165-176.
  7. Bridelli MG, Crippa PR (2008) Theoretical analysis of the adsorption of metal ions to the surface of melanin particles. Adsorption 14: 101-109.
  8. Abbruzzetti S, Bruno S, Faggiano S, Ronda L, Grandi E, Mozzarelli A, Viappiani C (2008) Characterization of ligand migration mechanisms inside haemoglobins from the analysis of geminate rebinding kinetics. Methods in Enzymology - Globins and other NO-reactive Proteins in Microbes, Plants and Invertebrates 437: 329-345.
  9. Ronda L, Abbruzzetti S, Bruno S, Bettati S, Mozzarelli A, Viappiani C (2008) Ligand-Induced Tertiary Relaxations During the T-to-R Quaternary Transition in Hemoglobin. Journal of Physical Chemistry B 112: 12790–12794.
  10. Ronda L, Bruno S, Abbruzzetti S, Viappiani C, Bettati S (2008) Ligand reactivity and allosteric regulation of hemoglobin-based oxygen carriers. Biochimica et Biophysica Acta - Proteins and Proteomics 1784: 1365–1377.
  11. Voliani V, Bizzarri R, Nifosı R, Abbruzzetti S, Grandi E, Viappiani C, Beltram F (2008) Cis-Trans Photoisomerization of Fluorescent-Protein Chromophores. Journal of Physical Chemistry B 112: 10714-10722.

 

2007

  1. Stingo S, Masullo M, Polverini E, Laezza C, Ruggiero I, Arcone R, Ruozi E, Piaz FD, Malfitano AM, D'Ursi AM, Bifulco M (2007) The N-terminal domain of 2,3-cyclic nucleotide 3-phosphodiesterase harbors a GTP/ATP binding site. Chemical Biology and Drug Design 70: 502-510.
  2. Haas H, Steitz R, Fasano A, Liuzzi GM, Polverini E, Cavatorta P, Riccio P (2007) Laminar order within Langmuir-Blodgett multilayers from phospholipid and myelin basic protein: A neutron reflectivity study. Langmuir 23: 8491-8496.
  3. Mazzini A, Polverini E, Parisi M, Sorbi RT, Favilla R (2007) Dissociation and unfolding of bovine odorant binding protein at acidic pH. Journal of Structural Biology 159: 82-91.
  4. Martens E, Leyssen A, Van Aelst I, Fiten P, Piccard H, Hu J, Descamps FJ, Van den Steen PE, Proost P, Van Damme J, Liuzzi GM, Riccio P, Polverini E, Opdenakker G (2007) A monoclonal antibody inhibits gelatinase B/MMP-9 by selective binding to part of the catalytic domain and not to the fibronectin or zinc binding domains. Biochimica et Biophysica Acta - General Subjects 1770: 178-186.
  5. Losi A (2007) Flavin-based blue-light photosensors: A photobiophysics update. Photochemistry and Photobiology 83: 1283-1300.
  6. Buttani V, Gärtner W, Losi A (2007) NTP-binding properties of the blue-light receptor YtvA and effects of the E105L mutation. European Biophysics Journal 36: 831-839.
  7. Drepper T, Eggert T, Circolone F, Heck A, Krauss U, Guterl JK, Wendorff M, Losi A, Gärtner W, Jaeger KE (2007) Reporter proteins for in vivo fluorescence without oxygen. Nature Biotechnology 25: 443-445.
  8. Buttani V, Losi A, Eggert T, Krauss U, Jaeger KE, Cao Z, Gärtner W (2007) Conformational analysis of the blue-light sensing protein YtvA reveals a competitive interface for LOV-LOV dimerization and interdomain interactions. Photochemical and Photobiological Sciences 6: 41-49.
  9. Abbruzzetti S, Grandi E, Bruno S, Faggiano S, Spyrakis F, Mozzarelli A, Dominici P, Viappiani C (2007) Ligand migration in non symbiotic hemoglobin AHb1 from Arabidopsis thaliana. Journal of Physical Chemistry B 111: 12582-12590.
  10. Bizzarri R, Nifosì R, Abbruzzetti S, Rocchia W, Guidi S, Arosio D, Garau G, Campanini B, Grandi E, Ricci F, Viappiani C, Beltram F (2007) Green Fluorescent Protein ground states: the influence of a second protonation site near the chromophore. Biochemistry 46: 5494-5504.
  11. Bruno S, Faggiano S, Spyrakis F, Mozzarelli A, Abbruzzetti S, Grandi E, Viappiani C, Feis A, Mackowiak S, Smulevich G, Cacciatori E, Dominici P (2007) The reactivity with CO of AHb1 and AHb2 fromArabidopsis thaliana is controlled by the distal His E7 and internal hydrophobic cavities. Journal of the American Chemical Society 129: 2880-2889.
  12. Bruno S, Faggiano S, Spyrakis F, Mozzarelli A, Cacciatori E, Dominici P, Grandi E, Abbruzzetti S, Viappiani C (2007) Different roles of protein dynamics and ligand migration in non-symbiotic hemoglobins AHb1 and AHb2 from Arabidopsis thaliana. Gene 398: 224–233.
  13. Eaton WA, Henry ER, Hofrichter J, Bettati S, Viappiani C, Mozzarelli A (2007) Evolution of allosteric models for hemoglobin. IUBMB Life 59: 586-599.

 

2006

  1. Buttani V, Losi A, Polverini E, Gärtner W (2006) Blue news: NTP binding properties of the blue-light sensitive YtvA protein from Bacillus subtilis. FEBS Letters 580: 3818-3822.
  2. Casoli C, Pilotti E, Perno CF, Balestra E, Polverini E, Cassone A, Conti S, Magliani W, Polonelli L (2006) A killer mimotope with therapeutic activity against AIDS-related opportunistic micro-organisms inhibits ex-vivo HIV-1 replication. AIDS 20: 975-980.
  3. Polverini E, Fornabaio M, Fasano A, Carlone G, Riccio P, Cavatorta P (2006) The pH-dependent unfolding mechanism of P2 myelin protein: An experimental and computational study. Journal of Structural Biology 153: 253-263.
  4. Bridelli MG, Ciati A, Crippa PR (2006) Binding of chemicals to melanins re-examined: Adsorption of some drugs to the surface of melanin particles. Biophysical Chemistry 119: 137-145.
  5. Abbruzzetti S, Bruno S, Faggiano S, Grandi E, Mozzarelli A, Viappiani C (2006) Time-resolved methods in Biophysics. 2. Monitoring haem proteins at work with nanosecond laser flash photolysis. Photochemical and Photobiological Sciences 5: 1109-1120.
  6. Abbruzzetti S, Sottini S, Viappiani C, Corrie JET (2006) Acid-induced unfolding of myoglobin triggered by a laser pH-jump method. Photochemical and Photobiological Sciences 5: 621–628.
  7. Campanini B, Schiaretti F, Abbruzzetti S, Kessler D, Mozzarelli A (2006) Sulfur Mobilization in Cyanobacteria THE CATALYTIC MECHANISM OF L-CYSTINE C-S LYASE (C-DES) FROM SYNECHOCYSTIS. Journal of  Biological Chemistry 281: 38769–38780.
  8. Gensch T, Heberle J, Viappiani C (2006) Proton transfer in biological systems. Photochemical and Photobiological Sciences 5: 529-530.
  9. Gensch T, Viappiani C (2006) Introducing the Time-resolved methods in biophysics series. Photochemical and Photobiological Sciences 5: 1101-1102.
  10. Polverini E, Cugini G, Annoni F, Abbruzzetti S, Viappiani C, Gensch T (2006) Molten globule formation in apomyoglobin monitored by the fluorescent probe nile red. Biochemistry 45: 5111 - 5121.
  11. Ronda L, Bruno S, Viappiani C, Abbruzzetti S, Mozzarelli A, Lowe KC, Bettati S (2006) Circular dichroism spectroscopy of tertiary and quaternary conformations of human hemoglobin entrapped in wet silica gels. Protein Science 15: 1961-1967.

 

2005

  1. Losi A, Ghiraldelli E, Jansen S, Gärtner W (2005) Mutational effects on protein structural changes and interdomain interactions in the blue-light sensing LOV protein YtvA. Photochemistry and Photobiology 81: 1145-1152.
  2. Krauss U, Losi A, Gärtner W, Jaeger KE, Eggert T (2005) Initial characterization of a blue-light sensing, phototropin-related protein from Pseudomonas putida: A paradigm for an extended LOV construct. Physical Chemistry Chemical Physics 7: 2804-2811.
  3. Losi A, Gensch T, Van Der Horst MA, Hellingwerf KJ, Braslavsky SE (2005) Hydrogen-bond network probed by time-resolved optoacoustic spectroscopy: Photoactive yellow protein and the effect of E46Q and E46A mutations. Physical Chemistry Chemical Physics 7: 2229-2236.
  4. Abbruzzetti S, Giuffrida S, Sottini S, Viappiani C, Cordone L (2005) Light-Induced Protein-Matrix Uncoupling and Protein Relaxation in Dry Samples of Trehalose Coated MbCO at Room Temperature. Cell Biochemistry and Biophysics 43: 431-438.
  5. Abbruzzetti S, Grandi E, Viappiani C, Bologna S, Campanini B, Raboni S, Bettati S, Mozzarelli A (2005) Kinetics of Acid-Induced Spectral Changes in the GFPmut2 Chromophore. Journal of the American Chemical Society 127: 626-635.
  6. Abbruzzetti S, Sottini S, Viappiani C, Corrie JET (2005) Kinetics of proton release after flash photolysis of 1-(2-nitrophenyl)ethyl sulfate (caged sulfate) in aqueous solutions. Journal of the American Chemical Society 127: 9865 - 9874.
  7. Cordone L, Cottone G, Giuffrida S, Palazzo G, Venturoli G, Viappiani C (2005) Internal dynamics and protein–matrix coupling in trehalose-coated proteins. Biochimica et Biophysica Acta - Proteins and Proteomics 1749: 252– 281.
  8. Sottini S, Abbruzzetti S, Spyrakis F, Bettati S, Ronda L, Mozzarelli A, Viappiani C (2005) Geminate rebinding in R state hemoglobin: kinetic and computational evidence for multiple hydrophobic pockets. Journal of the American Chemical Society 127: 17427-17432.
  9. Sottini S, Abbruzzetti S, Viappiani C, Bettati S, Ronda L, Mozzarelli A (2005) Evidence for two geminate rebinding states following laser photolysis of R state hemoglobin encapsulated in wet silica gels. Journal of Physical Chemistry B 109: 11411-11413.
  10. Sottini S, Abbruzzetti S, Viappiani C, Ronda L, Mozzarelli A (2005) Determination of microscopic rate constants for CO binding and migration in myoglobin encapsulated in silica gels. Journal of Physical Chemistry B 109: 19523 - 19528.

 

2004

  1. Polverini E, Boggs JM, Bates IR, Harauz G, Cavatorta P (2004) Electron paramagnetic resonance spectroscopy and molecular modelling of the interaction of myelin basic protein (MBP) with calmodulin (CaM)-diversity and conformational adaptability of MBP CaM-targets. Journal of Structural Biology 148: 353-369.
  2. Haas H, Oliveira CLP, Torriani IL, Polverini E, Fasano A, Carlone G, Cavatorta P, Riccio P (2004) Small Angle X-Ray Scattering from Lipid-Bound Myelin Basic Protein in Solution. Biophysical journal 86: 455-460.
  3. Losi A, Ternelli E, Gärtner W (2004) Tryptophan fluorescence in the Bacillus subtilis phototropin-related protein YtvA as a marker of interdomain interaction. Photochemistry and Photobiology 80: 150-153.
  4. Bednarz T, Losi A, Gärtner W, Hegemann P, Heberle J (2004) Functional variations among LOV domains as revealed by FT-IR difference spectroscopy. Photochemical and Photobiological Sciences 3: 575-579.
  5. Losi A (2004) The bacterial counterparts of plant phototropins. Photochemical and Photobiological Sciences 3: 566-574.
  6. Losi A, Kottke T, Hegemann P (2004) Recording of Blue Light-Induced Energy and Volume Changes within the Wild-Type and Mutated Phot-LOV1 Domain from Chlamydomonas reinhardtii. Biophysical journal 86: 1051-1060.
  7. Abbruzzetti S, Viappiani C, Sinibaldi F, Santucci R (2004) Kinetics of histidine deligation from the heme Fe(III) in N-fragment (residues 1-56) of cytochrome c. The Protein Journal 23: 519-527.
  8. Banderini A, Sottini S, Viappiani C (2004) Method for detecting extended real-time kinetics in nanosecond laser flash photolysis experiments. Review of Scientific Instruments 75: 2257-2261.
  9. Bettati S, Pioselli B, Campanini B, Viappiani C, Mozzarelli A (2004) Protein-Doped Nanoporous Silica Gels. In: Nalwa HS, editor. Encyclopedia of Nanoscience and Nanotechnology: American Scientific Publishers. pp. 81-103.
  10. Schiaretti F, Bettati S, Viappiani C, Mozzarelli A (2004) pH Dependence of Tryptophan Synthase Catalytic Mechanism: I. The first stage, the beta-elimination reaction. Journal of Biological Chemistry 279: 29572-29582.
  11. Sottini S, Viappiani C, Ronda L, Bettati S, Mozzarelli A (2004) CO rebinding kinetics to myoglobin- and R state hemoglobin- doped silica gels in the presence of glycerol. Journal of Physical Chemistry B 108: 8475-8484.
  12. Viappiani C, Bettati S, Bruno S, Ronda L, Abbruzzetti S, Mozzarelli A, Eaton AW (2004) New insights into allosteric mechanisms from trapping unstable protein conformations in silica gels. Proceedings of the National Academy of Science USA 101: 14414–14419

 

2003

  1. Polverini E, Arisi S, Cavatorta P, Berzina T, Cristofolini L, Fasano A, Riccio P, Fontana MP (2003) Interaction of myelin basic protein with phospholipid monolayers: Mechanism of protein penetration. Langmuir 19: 872-877.
  2. Gärtner W, Losi A (2003) Crossing the borders: Archaeal rhodopsins go bacterial. Trends in Microbiology 11: 405-407.
  3. Losi A, Quest B, Gärtner W (2003) Listening to the blue: The time-resolved thermodynamics of the bacterial blue-light receptor YtvA and its isolated LOV domain. Photochemical and Photobiological Sciences 2: 759-766.
  4. Losi A, Yruela I, Reus M, Holzwarth AR, Braslavsky SE (2003) Structural changes upon excitation of D1-D2-Cyt b559 photosystem II reaction centers depend on the β-carotene content. Photochemical and Photobiological Sciences 2: 722-729.
  5. Losi A, Braslavsky SE (2003) The time-resolved thermodynamics of the chromophore-protein interactions in biological photosensors as derived from photothermal measurements. Physical Chemistry Chemical Physics 5: 2739-2750.
  6. Abbruzzetti S, Carcelli M, Rogolino D, Viappiani C (2003) Deprotonation yields, pKa, and aci-nitro decay rates in some substituted o-nitrobenzaldehydes. Photochemical and Photobiological Sciences 2: 796–800.
  7. Bacchi A, Carcelli M, Pelizzi C, Pelizzi G, Pelagatti P, Rogolino D, Tegoni M, Viappiani C (2003) Synthesis, spectroscopic and structural characterization of two novel photoactivatable Ca2+ compounds. Inorganic Chemistry 42: 5871-5879.
  8. Diaspro A, Federici F, Viappiani C, Krol S, Pisciotta M, Chirico G, Cannone F, Gliozzi A (2003) Two-photon photolysis of 2-nitrobenzaldehyde monitored by fluorescent labeled nanocapsules. Journal of Physical Chemistry B 107: 11008-11012.
  9. Gensch T, Viappiani C (2003) Time-resolved photothermal methods: accessing time-resolved thermodynamics of photoinduced processes in chemistry and biology. Photochemical and Photobiological Sciences 2: 699–721.

 

2002

  1. Losi A, Polverini E, Quest B, Gärtner W (2002) First evidence for phototropin-related blue-light receptors in prokaryotes. Biophysical journal 82: 2627-2634.
  2. Bridelli MG, Capelletti R, Mora C, Pirola L, Ronda L. Dielectric properties of proteins encapsulated in silica gel; 2002. pp. 267-270.
  3. Bridelli MG, Capelletti R, Maraia F, Mora C, Pirola L (2002) Initial hydration steps in lipase studied by means of water sorption isotherms, FTIR spectroscopy and thermally stimulated depolarization currents. Journal of Physics D: Applied Physics 35: 1039-1048.
  4. Librizzi F, Viappiani C, Abbruzzetti S, Cordone L (2002) Residual water modulates the dynamics of the protein and of the external matrix in "trehalose coated" MbCO: an infrared and flash photolysis study. Journal of Chemical Physics 116: 1193-1200.

 

2001

  1. Losi A, Wegener AA, Engelhard M, Braslavsky SE (2001) Thermodynamics of the early steps in the photocycle of Natronobacterium pharaonis halorhodopsin. Influence of medium and of anion substitution. Photochemistry and Photobiology 74: 495-503.
  2. Losi A, Wegener AA, Engelhard M, Braslavsky SE (2001) Enthalpy-entropy compensation in a photocycle: The K-to-L transition in sensory rhodopsin II from Natronobacterium pharaonis [4]. Journal of the American Chemical Society 123: 1766-1767.
  3. Abbruzzetti S, Carcelli M, Pelagatti P, Rogolino D, Viappiani C (2001) Photoinduced alkaline pH-jump on the nanosecond time scale. Chemical Physics Letters 344: 387-394.
  4. Abbruzzetti S, Viappiani C, Bruno S, Bettati S, Bonaccio M, Mozzarelli A (2001) Functional Characterization of Heme Proteins Encapsulated in Wet Nanoporous Silica Gels. Journal of Nanoscience and Nanotechnology 1: 407-415.
  5. Abbruzzetti S, Viappiani C, Bruno S, Mozzarelli A (2001) Enhanced geminate ligand rebinding upon photo-dissociation of silica gel-embedded myoglobin-CO. Chemical Physics Letters 346: 430-436.
  6. Abbruzzetti S, Viappiani C, Small JR, Libertini LJ, Small EW (2001) Kinetics of histidine deligation from the heme in GuHCl unfolded Fe(III) cytochrome c studied by a laser induced pH-jump technique. Journal of the American Chemical Society 123: 6649-6653.
  7. Bruno S, Bonaccio M, Bettati S, Rivetti C, Viappiani C, Abbruzzetti S, Mozzarelli A (2001) High and low oxygen affinity conformations of T state hemoglobin. Protein Science 10: 2401-2407

 

2000

  1. Lanteri N, Rolandi R, Cavatorta P, Polverini E, Riccio P, Gliozzi A (2000) Myelin basic protein-lipid complex: An atomic force microscopy study. Colloids and Surfaces A: Physicochemical and Engineering Aspects 175: 3-9.
  2. Bates IR, Matharu P, Ishiyama N, Rochon D, Wood DD, Polverini E, Moscarello MA, Viner NJ, Harauz G (2000) Characterization of a recombinant murine 18.5-kDa myelin basic protein. Protein Expression and Purification 20: 285-299.
  3. Losi A, Michler I, Gärtner W, Braslavsky SE (2000) Time-resolved thermodynamic changes photoinduced in 5,12-trans-locked bacteriorhodopsin. Evidence that retinal isomerization is required for protein activation. Photochemistry and Photobiology 72: 590-597.
  4. Losi A, Wegener AA, Engelhard M, Gärtner W, Braslavsky SE (2000) Aspartate 75 mutation in sensory rhodopsin II from Natronobacterium pharaonis does not influence the production of the K-like intermediate, but strongly affects its relaxation pathway. Biophysical journal 78: 2581-2589.
  5. Abbruzzetti S, Crema E, Masino L, Vecli A, Viappiani C, Small JR, Libertini LJ, Small EW (2000) Fast events in protein folding. Structural volume changes accompanying the early events in the N->I transition of apomyoglobin induced by ultrafast pH jump. Biophysical Journal 78: 405-415.
  6. Abbruzzetti S, Viappiani C, Small JR, Libertini LJ, Small EW (2000) Kinetics of local helix formation in poly-L-glutamic acid studied by time-resolved photoacoustics: neutralization reactions of carboxylates in aqueous solutions and their relevance to the problem of protein folding. Biophysical Journal 79: 2714-2721.
  7. Pispisa B, Stella L, Venanzi M, Palleschi A, Viappiani C, Polese A, Toniolo C (2000) Quenching mechanism in bichromophoric 310-helical AIB-based peptides, modulated by chain length-dependent topologies. Macromolecules 33: 906-915
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Biophysics

Biophysics researchers active in this Department apply spectroscopic and computational methods to study structural and dynamical properties of biological macromolecules and their interactions with the environment.
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